Endocrine Abstracts

Aim: Low sex hormone-binding globulin (SHBG) is accompanied with onset of diabetes (DM) and increased cardiovascular risk (CVR). Proinflammatory cytokines, including adiponectin (APN) influence SHBG production. Lipid accumulation product (LAP) advocates as an indicator of increased CVR. We investigated the influence of different types of DM and sex on CVR through changes in SHBG and related risk factors.Methods: Due to the non-normal distribution of indi...

Introduction: Patients with diabetes (DM) are at increased risk for cardiovacular disease (CVD). Possible effects of insulin therapy on development of atherosclerosis and CVD were studied.Patients and methods: Relevant metabolic parameters were determined in 348 patients assigned into groups with DM2 on oral hypoglycemic drugs (DM2-OH) and insulin (DM2-INS), and with DM1.Results: A significant among-group difference was found in ad...

Kisspeptin produced by placenta is involved in the regulation of early placental development. Aberrant placental development and placental dysfunction are common in pregnancies with diabetes and hypertension. Parameters of fetal growth, feto-placental circulation, pregnancy outcome, placental weight and morphology were recorded and correlated with kisspeptin levels in pregnant women with diabetes (chronic insulin dependent-IDDM and gestational-GD) and hypertension (chronic-H, ...

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...